Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 3/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13568091 | 0.69 | TSHR (0.34) | — | |
| SCHEMBL945843 | 0.69 | — | — | |
| SCHEMBL13743863 | 0.64 | GRM5 (0.45) | ATMNMT1HSP90AA1TDP1 | |
| SCHEMBL21252647 | 0.63 | — | — | |
| SCHEMBL3347212 | 0.61 | TDP1 (0.40) | ATMNMT1L3MBTL1HSP90AA1TDP1 | |
| Benzonitrile SCHEMBL8216189 | 0.60 | FNTA (0.42) | ATMHSP90AA1TDP1FNTAFNTB | |
| SCHEMBL12590718 | 0.60 | TDP1 (0.38) | ATMNMT1L3MBTL1HSP90AA1TDP1 | |
| SCHEMBL18430927 | 0.60 | TDP1 (0.38) | ATMNMT1L3MBTL1HSP90AA1TDP1 | |
| SCHEMBL14986261 | 0.60 | — | — | |
| SCHEMBL12820173 | 0.59 | TDP1 (0.44) | ATML3MBTL1HSP90AA1TDP1UBE2N |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |