Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653252 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTTP53PDE10ARAB9A | |
| SCHEMBL21653120 | 0.87 | GSK3B (0.39) | SMN1; SMN2MAPTTP53PDE10ARAB9A | |
| SCHEMBL21653084 | 0.85 | MAPT (0.39) | SMN1; SMN2MAPTTP53PDE10ARAB9A | |
| SCHEMBL21653251 | 0.85 | GSK3B (0.38) | SMN1; SMN2MAPTTP53PDE10ARAB9A | |
| SCHEMBL21653245 | 0.85 | USP7 (0.38) | SMN1; SMN2MAPTTP53PDE10AKDM4E | |
| SCHEMBL21653156 | 0.84 | PDE10A (0.38) | SMN1; SMN2MAPTTP53PDE10ARAB9A | |
| SCHEMBL21653150 | 0.83 | GSK3B (0.36) | SMN1; SMN2MAPTTP53PDE10AKDM4E | |
| SCHEMBL21653138 | 0.82 | MAPT (0.39) | SMN1; SMN2MAPTTP53PDE10AKDM4E | |
| SCHEMBL21653145 | 0.82 | GSK3B (0.35) | SMN1; SMN2MAPTTP53PDE10AALDH1A1 | |
| SCHEMBL21652873 | 0.82 | GSK3B (0.35) | SMN1; SMN2MAPTTP53PDE10AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |