Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653145 | 0.92 | GSK3B (0.35) | GSK3BDAOMAPTTP53KDM4E | |
| SCHEMBL21653120 | 0.90 | GSK3B (0.39) | GSK3BDAOMAPTTP53KDM4E | |
| SCHEMBL21653084 | 0.88 | MAPT (0.39) | GSK3BDAOMAPTTP53KDM4E | |
| SCHEMBL21653269 | 0.87 | BRD4 (0.39) | MAPTTP53KDM4EPDE10ASMN1; SMN2 | |
| SCHEMBL21653156 | 0.87 | PDE10A (0.38) | GSK3BDAOMAPTTP53KDM4E | |
| SCHEMBL21653150 | 0.86 | GSK3B (0.36) | GSK3BDAOMAPTTP53KDM4E | |
| SCHEMBL21653136 | 0.85 | SMN1; SMN2 (0.47) | MAPTTP53KDM4EALDH1A1PDE10A | |
| SCHEMBL21653138 | 0.85 | MAPT (0.39) | GSK3BDAOMAPTTP53KDM4E | |
| SCHEMBL21652873 | 0.85 | GSK3B (0.35) | GSK3BDAOMAPTTP53KDM4E | |
| SCHEMBL21653276 | 0.84 | L3MBTL1 (0.36) | GSK3BDAOMAPTTP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |