Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653390 | 0.85 | SMN1; SMN2 (0.44) | RXFP1RAB9ANPC1CYP1A2CYP2D6 | |
| SCHEMBL21653103 | 0.84 | KDM1A (0.42) | RXFP1RAB9ANPC1CYP1A2CYP2D6 | |
| SCHEMBL21653263 | 0.84 | ALDH1A1 (0.42) | RXFP1RAB9ANPC1CYP1A2CYP2D6 | |
| SCHEMBL21653236 | 0.83 | RXFP1 (0.39) | RXFP1RAB9ANPC1CYP1A2CYP2D6 | |
| SCHEMBL21652890 | 0.83 | KDM4E (0.41) | RXFP1RAB9ANPC1CYP1A2CYP2D6 | |
| SCHEMBL21653237 | 0.82 | ALDH1A1 (0.41) | RXFP1RAB9ANPC1CYP1A2CYP2D6 | |
| SCHEMBL21653128 | 0.81 | ALDH1A1 (0.40) | RXFP1RAB9ANPC1CYP1A2CYP2D6 | |
| SCHEMBL21653107 | 0.81 | ALDH1A1 (0.40) | RXFP1RAB9ANPC1CYP1A2CYP2D6 | |
| SCHEMBL21653241 | 0.77 | RXFP1 (0.43) | RXFP1TP53SMN1; SMN2THRBMAPT | |
| SCHEMBL21653144 | 0.74 | KDM4E (0.37) | RXFP1RAB9ANPC1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |