Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22746497 | 0.90 | GAA (0.46) | TP53SMN1; SMN2HTTCRHBPCRHR2 | |
| SCHEMBL21649720 | 0.90 | GAA (0.46) | TP53SMN1; SMN2HTTCRHBPCRHR2 | |
| SCHEMBL23943397 | 0.88 | MEN1 (0.40) | KMT2AMEN1TP53SMN1; SMN2HTT | |
| SCHEMBL23943398 | 0.88 | MEN1 (0.40) | KMT2AMEN1TP53SMN1; SMN2HTT | |
| SCHEMBL24496722 | 0.88 | KMT2A (0.46) | KMT2AMEN1TP53SMN1; SMN2ATM | |
| SCHEMBL27123687 | 0.87 | HDAC3 (0.47) | KMT2AMEN1TP53SMN1; SMN2ATM | |
| SCHEMBL26445311 | 0.87 | HDAC1 (0.45) | TP53HTTHDAC3HDAC4HDAC1 | |
| SCHEMBL25774296 | 0.86 | MEN1 (0.43) | KMT2AMEN1TP53SMN1; SMN2HTT | |
| SCHEMBL22064637 | 0.86 | SMN1; SMN2 (0.47) | KMT2AMEN1TP53SMN1; SMN2ATM | |
| SCHEMBL21650353 | 0.84 | KMT2A (0.42) | KMT2AMEN1TP53SMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020216947-A1 | AMATOXIN ANTIBODY-DRUG CONJUGATES AND USES THEREOF | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2020-10-29 | — | — | WO | disclosed |
| WO-2020219748-A2 | ANTI-CD117 ANTIBODIES AND USES THEREOF | Magenta Therapeutics, Inc. (US) | 2020-10-29 | — | — | WO | disclosed |
| WO-2020219770-A1 | ANTI-CD117 ANTIBODIES AND USES THEREOF | Magenta Therapeutics, Inc. (US) | 2020-10-29 | — | — | WO | disclosed |
| WO-2020023561-A1 | USE OF ANTI-CD5 ANTIBODY DRUG CONJUGATE (ADC) IN ALLOGENEIC CELL THERAPY | Magenta Therapeutics, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |