Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | FURIN | P09958 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22266610 | 0.89 | HTT (0.41) | SMN1; SMN2TP53KMT2AMEN1ATM | |
| SCHEMBL15099992 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2TP53KMT2AMEN1ATM | |
| SCHEMBL21657990 | 0.86 | KMT2A (0.45) | SMN1; SMN2TP53KMT2AMEN1ATM | |
| SCHEMBL24496722 | 0.82 | KMT2A (0.46) | SMN1; SMN2TP53KMT2AMEN1ATM | |
| SCHEMBL27123687 | 0.81 | HDAC3 (0.47) | SMN1; SMN2TP53KMT2AMEN1ATM | |
| SCHEMBL13775166 | 0.80 | CRHBP (0.50) | SMN1; SMN2TP53KMT2AMEN1ATM | |
| SCHEMBL23330668 | 0.79 | HTT (0.39) | SMN1; SMN2TP53KMT2AMEN1HTT | |
| SCHEMBL14862556 | 0.78 | HTT (0.43) | SMN1; SMN2TP53KMT2AMEN1ATM | |
| SCHEMBL17593772 | 0.78 | HTT (0.43) | SMN1; SMN2TP53KMT2AMEN1ATM | |
| SCHEMBL20067564 | 0.78 | USP2 (0.45) | SMN1; SMN2TP53KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230233703-A1 | AMANITIN CONJUGATES | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2023-07-27 | — | — | US | disclosed |
| US-10961277-B2 | Method for synthesizing amanitins | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2021-03-30 | — | — | US | disclosed |
| US-20200181200-A1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233703-A1 | AMANITIN CONJUGATES | CD47, MTX1, SIGLEC7 | SMN1; SMN2 2480/4885TP53 1146/4885KMT2A 1722/4885 |
| US-20200181200-A1 | NOVEL METHOD FOR SYNTHESIZING AMANITINS | CIAPIN1, ANXA5, AANAT | SMN1; SMN2 4801/4885TP53 2404/4885KMT2A 2301/4885 |
| US-10961277-B2 | Method for synthesizing amanitins | CIAPIN1, AANAT, ANXA5 | SMN1; SMN2 4795/4885TP53 1547/4885KMT2A 1600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.