Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24915359 | 0.82 | LMNA (0.38) | KDM5AIDH1DHODHLMNADRD2 | |
| SCHEMBL23120463 | 0.76 | SMN1; SMN2 (0.56) | LMNA | |
| SCHEMBL30912557 | 0.76 | DHODH (0.40) | IDH1DHODHLMNADRD2DRD4 | |
| SCHEMBL21658766 | 0.74 | KAT2B (0.42) | KDM5AIDH1DHODHLMNADRD2 | |
| SCHEMBL21659038 | 0.72 | TYK2 (0.36) | KDM5ADHODHSLC5A2 | |
| SCHEMBL16794667 | 0.72 | DHODH (0.40) | IDH1DHODHLMNADRD2DRD4 | |
| SCHEMBL16651267 | 0.72 | KDM5A (0.44) | KDM5AIDH1DHODHLMNAPDE4A | |
| SCHEMBL1857401 | 0.72 | LMNA (0.43) | IDH1DHODHLMNADRD2DRD4 | |
| SCHEMBL25286678 | 0.71 | DPP4 (0.40) | IDH1LMNAGLAPOLB | |
| Hydrochloric Acid SCHEMBL25434975 | 0.70 | DHODH (0.39) | IDH1DHODHLMNADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023846-A1 | PYRIDONE A2R ANTAGONISTS | ARCUS BIOSCIENCES, INC. (US) | 2020-01-30 | — | — | WO | disclosed |