Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 6/20 | 0.39 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 3/20 | 0.35 |
| ▸ | GLP1R | P43220 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.34 |
| ▸ | IL1B | P01584 | 3/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21659038 | 0.91 | TYK2 (0.36) | TYK2KDM5ASLC5A2 | |
| SCHEMBL24915359 | 0.83 | LMNA (0.38) | P2RX7KDM5ASLC5A2 | |
| SCHEMBL21659048 | 0.79 | KAT2B (0.36) | TYK2IL4I1 | |
| SCHEMBL23426313 | 0.79 | TYK2 (0.36) | TYK2IL4I1GLP1RP2RX7IL1B | |
| SCHEMBL20688516 | 0.78 | TYK2 (0.41) | TYK2IL4I1HTR3ALCK | |
| SCHEMBL20689379 | 0.78 | TYK2 (0.41) | TYK2IL4I1HTR3ALCK | |
| SCHEMBL16812514 | 0.78 | TYK2 (0.41) | TYK2IL4I1HTR3ALCK | |
| SCHEMBL20688037 | 0.74 | TYK2 (0.52) | TYK2 | |
| SCHEMBL20697279 | 0.74 | MAPT (0.40) | TYK2 | |
| SCHEMBL20687701 | 0.74 | TYK2 (0.52) | TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023846-A1 | PYRIDONE A2R ANTAGONISTS | ARCUS BIOSCIENCES, INC. (US) | 2020-01-30 | — | — | WO | disclosed |