Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSH | P09668 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20656041 | 0.88 | SLC6A2 (0.35) | SLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL22890900 | 0.80 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3KDM1ACTSL | |
| SCHEMBL27055532 | 0.79 | BCHE (0.39) | SLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL15316722 | 0.76 | CHKA (0.40) | KDM1A | |
| SCHEMBL10192139 | 0.76 | KDM1A (0.39) | KDM1A | |
| SCHEMBL24925644 | 0.76 | HTR1A (0.43) | KDM1A | |
| SCHEMBL25804761 | 0.74 | HRH3 (0.36) | SLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL20656066 | 0.73 | HRH3 (0.34) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24461609 | 0.72 | KDM1A (0.39) | SLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL27051363 | 0.72 | KDM1A (0.39) | SLC6A2SLC6A4SLC6A3KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024100139-A1 | USE OF IFN-I ACTIVITY AS A BIOMARKER FOR TLR INHIBITOR TREATMENT | MERCK PATENT GMBH (DE) | 2024-05-16 | — | — | WO | disclosed |
| WO-2020025517-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | WO | disclosed |