Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.36 |
| ▸ | HTR1A | P08908 | 6/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | STK3 | Q13188 | 1/20 | 0.33 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21661354 | 1.00 | KDM4E (0.37) | KDM4ERAD52L3MBTL1NCF1TLR7 | |
| SCHEMBL21661470 | 0.93 | KDM4E (0.38) | KDM4ERAD52L3MBTL1NCF1TLR7 | |
| SCHEMBL16633863 | 0.86 | TLR9 (0.48) | KDM4ERAD52L3MBTL1TLR7TLR9 | |
| SCHEMBL16633866 | 0.86 | TLR9 (0.48) | KDM4ERAD52L3MBTL1TLR7TLR9 | |
| SCHEMBL21661609 | 0.85 | NCF1 (0.41) | KDM4ERAD52L3MBTL1NCF1TLR7 | |
| SCHEMBL21661610 | 0.85 | NCF1 (0.41) | KDM4ERAD52L3MBTL1NCF1TLR7 | |
| SCHEMBL18980379 | 0.85 | TLR7 (0.40) | KDM4ERAD52L3MBTL1NCF1TLR7 | |
| SCHEMBL18980767 | 0.85 | TLR7 (0.40) | KDM4ERAD52L3MBTL1NCF1TLR7 | |
| SCHEMBL29722322 | 0.85 | TLR7 (0.40) | KDM4ERAD52L3MBTL1NCF1TLR7 | |
| SCHEMBL18980381 | 0.85 | TLR7 (0.40) | KDM4ERAD52L3MBTL1NCF1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020025517-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | WO | disclosed |