Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18980400 | 0.77 | L3MBTL1 (0.50) | HSP90AA1HTTKDM4EMEN1KMT2A | |
| SCHEMBL11910994 | 0.76 | KDM4E (0.52) | HSP90AA1HTTKDM4EMEN1KMT2A | |
| SCHEMBL11893023 | 0.74 | KMT2A (0.54) | HSP90AA1HTTKDM4EMEN1KMT2A | |
| SCHEMBL3380627 | 0.73 | MEN1 (0.58) | HSP90AA1HTTKDM4EMEN1KMT2A | |
| SCHEMBL21645154 | 0.73 | KDM4E (0.49) | HSP90AA1HTTKDM4EMEN1KMT2A | |
| SCHEMBL3381245 | 0.73 | KDM4E (0.49) | HSP90AA1HTTKDM4EMEN1KMT2A | |
| SCHEMBL19837171 | 0.72 | NSD2 (0.45) | HSP90AA1HTTKDM4EMEN1KMT2A | |
| SCHEMBL20278418 | 0.72 | KMT2A (0.45) | HSP90AA1HTTKDM4EMEN1KMT2A | |
| SCHEMBL7062239 | 0.71 | — | — | |
| SCHEMBL31420239 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020025517-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | WO | disclosed |