Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21645231 | 1.00 | KMT2A (0.40) | KMT2AMEN1GAALMNASMN1; SMN2 | |
| SCHEMBL21645166 | 0.87 | NCF1 (0.45) | KMT2AMEN1TDP1EIF2AK4KDM4E | |
| SCHEMBL16634109 | 0.86 | TLR8 (0.51) | GAASMN1; SMN2ALDH1A1TLR8TLR9 | |
| SCHEMBL16633347 | 0.86 | TLR8 (0.51) | GAASMN1; SMN2ALDH1A1TLR8TLR9 | |
| SCHEMBL19828894 | 0.86 | TLR8 (0.51) | GAASMN1; SMN2ALDH1A1TLR8TLR9 | |
| SCHEMBL16634353 | 0.86 | TLR8 (0.51) | GAASMN1; SMN2ALDH1A1TLR8TLR9 | |
| SCHEMBL21661509 | 0.84 | KDM4E (0.40) | KMT2AGAALMNAHTTSLC6A2 | |
| SCHEMBL21661052 | 0.84 | KDM4E (0.40) | KMT2AGAALMNAHTTSLC6A2 | |
| SCHEMBL21645266 | 0.84 | KDM4E (0.40) | KMT2AGAALMNAHTTSLC6A2 | |
| SCHEMBL19000120 | 0.82 | KMT2A (0.46) | KMT2AMEN1GAAHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020025517-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | WO | disclosed |