Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 10/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21661576 | 1.00 | KDM4E (0.37) | KDM4ERAD52L3MBTL1HTR1AHRH3 | |
| SCHEMBL21661470 | 0.84 | KDM4E (0.38) | KDM4ERAD52L3MBTL1HTR1AHRH3 | |
| SCHEMBL16633859 | 0.81 | TLR9 (0.49) | KDM4ERAD52L3MBTL1HRH3TLR9 | |
| SCHEMBL16633862 | 0.81 | TLR9 (0.49) | KDM4ERAD52L3MBTL1HRH3TLR9 | |
| SCHEMBL23893140 | 0.81 | HRH3 (0.39) | KDM4ERAD52L3MBTL1HTR1AHRH3 | |
| SCHEMBL21645266 | 0.81 | KDM4E (0.40) | KDM4EL3MBTL1HTT | |
| SCHEMBL21661509 | 0.81 | KDM4E (0.40) | KDM4EL3MBTL1HTT | |
| SCHEMBL21661052 | 0.81 | KDM4E (0.40) | KDM4EL3MBTL1HTT | |
| SCHEMBL16634343 | 0.81 | TLR8 (0.48) | KDM4ERAD52L3MBTL1HRH3TLR9 | |
| SCHEMBL24404851 | 0.81 | TLR8 (0.48) | KDM4ERAD52L3MBTL1HRH3TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020025517-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | WO | disclosed |