Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 4/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.31 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18980659 | 0.88 | HRH3 (0.39) | HRH3KDM4EHTTKMT2ARAD52 | |
| SCHEMBL21661451 | 0.88 | TLR9 (0.43) | HRH3KDM4EHTTTLR9TLR8 | |
| SCHEMBL18980366 | 0.88 | TLR9 (0.43) | HRH3KDM4EHTTTLR9TLR8 | |
| SCHEMBL18979959 | 0.87 | HRH3 (0.40) | HRH3KDM4EHTTKMT2ARAD52 | |
| SCHEMBL18980746 | 0.87 | TLR9 (0.42) | HRH3TLR9TLR8TLR7L3MBTL3 | |
| SCHEMBL21594159 | 0.83 | KDM4E (0.37) | HRH3KDM4EHTTKMT2ATLR9 | |
| SCHEMBL21594155 | 0.83 | KDM4E (0.37) | HRH3KDM4EHTTKMT2ATLR9 | |
| SCHEMBL21661577 | 0.81 | KDM4E (0.37) | HRH3KDM4EHTTTLR9TLR8 | |
| SCHEMBL21661576 | 0.81 | KDM4E (0.37) | HRH3KDM4EHTTTLR9TLR8 | |
| SCHEMBL18980185 | 0.81 | TLR9 (0.42) | IRAK4TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889146-A1 | POLYHETEROCYCLIC TLR7/8 ANTAGONISTS AND THEIR USES FOR TREATING IMMUNE DISORDERS | Merck Patent GmbH (DE) | 2021-10-06 | — | — | EP | disclosed |