Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.62 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.54 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | CLK3 | P49761 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21609941 | 0.90 | DYRK1A (0.59) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL21661775 | 0.86 | DYRK1A (0.70) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL21611022 | 0.83 | DYRK1A (0.64) | DYRK1ALRRK2 | |
| SCHEMBL21738336 | 0.82 | DYRK1A (0.63) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL21738232 | 0.82 | LRRK2 (0.52) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL22264376 | 0.80 | LRRK2 (0.66) | DYRK1ALRRK2 | |
| SCHEMBL21661930 | 0.78 | DYRK1A (0.82) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL29492980 | 0.78 | DYRK1A (0.86) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL21611072 | 0.78 | DYRK1A (0.86) | DYRK1ADYRK3CSNK1ECLK1CLK2 | |
| SCHEMBL21611052 | 0.77 | DYRK1A (1.00) | DYRK1ADYRK3CSNK1ECLK1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3604304-A1 | PYRROLO-PYRIDINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTEIN KINASE-RELATED DISEASES | Daegu-Gyeongbuk Medical Innovation Foundation (KR) | 2020-02-05 | — | — | EP | disclosed |