Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21738306 | 0.95 | LRRK2 (0.57) | LRRK2DYRK1ATTK | |
| SCHEMBL21738319 | 0.92 | LRRK2 (0.54) | LRRK2DYRK1ATTK | |
| SCHEMBL21609941 | 0.91 | DYRK1A (0.59) | LRRK2DYRK1ADYRK3CSNK1ECLK1 | |
| SCHEMBL21738336 | 0.88 | DYRK1A (0.63) | LRRK2DYRK1ADYRK3CSNK1ECLK1 | |
| SCHEMBL21738257 | 0.87 | DYRK1A (0.64) | LRRK2DYRK1ADYRK3CSNK1ECLK1 | |
| SCHEMBL22264376 | 0.86 | LRRK2 (0.66) | LRRK2DYRK1ATTK | |
| SCHEMBL22264320 | 0.85 | TTK (0.66) | LRRK2DYRK1ATTK | |
| SCHEMBL22264261 | 0.85 | LRRK2 (0.67) | LRRK2DYRK1ADYRK3CSNK1ECLK1 | |
| SCHEMBL21611022 | 0.85 | DYRK1A (0.64) | LRRK2DYRK1ATTK | |
| SCHEMBL21738247 | 0.83 | LRRK2 (0.61) | LRRK2DYRK1ATTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020036437-A1 | SUBSTITUTED HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES WHICH CONTAINS SAME AS ACTIVE INGREDIENT | 재단법인 대구경북첨단의료산업진흥재단 | 2020-02-20 | — | — | WO | disclosed |