Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.72 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.72 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.72 |
| ▸ | PIM1 | P11309 | 6/20 | 0.72 |
| ▸ | GSK3B | P49841 | 6/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.72 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2167169 | 0.91 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| SCHEMBL2166687 | 0.89 | PIK3CD (0.72) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| SCHEMBL1250307 | 0.88 | PIK3CD (0.74) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| SCHEMBL2165902 | 0.88 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| SCHEMBL1120284 | 0.87 | PIK3CD (0.72) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| SCHEMBL1119169 | 0.86 | PIK3CD (0.77) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| SCHEMBL1251763 | 0.86 | PIK3CD (0.74) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| SCHEMBL2213591 | 0.86 | PIK3CD (0.66) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| SCHEMBL2165027 | 0.86 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| SCHEMBL2164786 | 0.86 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIM1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280705-B1 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2014-10-08 | — | — | EP | claimed |
| US-8536169-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2013-09-17 | — | — | US | claimed |
| US-20110183973-A1 | Novel Compounds | GLAXO GROUP LIMITED (GB) | 2011-07-28 | — | — | US | claimed |
| US-9326987-B2 | Indazole derivatives for use in the treatment of influenza virus infection | GLAXO GROUP LIMITED (GB) | 2016-05-03 | — | — | US | disclosed |
| EP-2280705-B1 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2014-10-08 | — | — | EP | disclosed |
| US-8536169-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2013-09-17 | — | — | US | disclosed |
| US-8536169-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2013-09-17 | — | — | US | disclosed |
| US-20130165433-A1 | Novel Use | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2013-06-27 | — | — | US | disclosed |
| US-20110183973-A1 | Novel Compounds | GLAXO GROUP LIMITED (GB) | 2011-07-28 | — | — | US | disclosed |
| US-20110183973-A1 | Novel Compounds | GLAXO GROUP LIMITED (GB) | 2011-07-28 | — | — | US | disclosed |
| US-20110183973-A1 | Novel Compounds | GLAXO GROUP LIMITED (GB) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165433-A1 | Novel Use | HAVCR2, MAVS, ENTPD5 | PIK3CD 2938/4885PIK3CB 1706/4885PIK3CG 2718/4885 |
| US-20110183973-A1 | Novel Compounds | PIK3C2B, PIK3CD, PIK3CA | PIK3CD 2/4885PIK3CB 5/4885PIK3CG 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.