Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20128699 | 0.85 | HRH3 (0.43) | HRH3SIGMAR1 | |
| SCHEMBL24654227 | 0.83 | CHRNB4 (0.42) | HRH3 | |
| SCHEMBL20234232 | 0.83 | HRH3 (0.61) | HRH3SIGMAR1 | |
| SCHEMBL23350037 | 0.78 | HRH3 (0.44) | HRH3SIGMAR1 | |
| SCHEMBL21899199 | 0.70 | SLC6A2 (0.46) | HRH3 | |
| SCHEMBL20128705 | 0.69 | IDO1 (0.35) | — | |
| SCHEMBL20463266 | 0.68 | HRH3 (0.48) | HRH3SIGMAR1 | |
| SCHEMBL20129354 | 0.68 | HRH3 (0.35) | HRH3SIGMAR1 | |
| SCHEMBL20317557 | 0.68 | KDM4E (0.44) | HRH3 | |
| SCHEMBL20233912 | 0.68 | HRH3 (0.50) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200038513-A1 | MODULATORS OF FAK PROTEOLYSIS AND ASSOCIATED METHODS OF USE | YALE UNIVERSITY | 2020-02-06 | — | — | US | disclosed |
| US-20200038378-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | GENENTECH, INC. | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200038378-A1 | BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ADRM1, BRAP, VHL | HRH3 3459/4885KAT2B 1037/4885SIGMAR1 3355/4885 |
| US-20200038513-A1 | MODULATORS OF FAK PROTEOLYSIS AND ASSOCIATED METHODS OF USE | PTK2, CTTN, CRBN | HRH3 3687/4885KAT2B 2504/4885SIGMAR1 4091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.