Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23483049 | 0.90 | MEN1 (0.37) | KDM4EALDH1A1CYP2C19TDP1ADRB2 | |
| SCHEMBL24654423 | 0.84 | CES2 (0.56) | KDM4EALDH1A1CES2NPSR1CYP2C19 | |
| SCHEMBL24897599 | 0.84 | CYP2C19 (0.49) | KDM4EALDH1A1CES2NPSR1CYP2C19 | |
| SCHEMBL20325067 | 0.83 | KDM4E (0.38) | KDM4EALDH1A1CES2NPSR1CYP2C19 | |
| SCHEMBL19599821 | 0.83 | KDM4E (0.40) | KDM4EALDH1A1CES2NPSR1CYP2C19 | |
| SCHEMBL23695750 | 0.82 | KDM4E (0.43) | KDM4EALDH1A1NPSR1CYP2C19TDP1 | |
| SCHEMBL21107498 | 0.82 | KDM4E (0.43) | KDM4EALDH1A1NPSR1CYP2C19TDP1 | |
| SCHEMBL21026059 | 0.81 | KDM4E (0.39) | KDM4EALDH1A1CES2NPSR1CYP2C19 | |
| SCHEMBL21477210 | 0.81 | CES2 (0.53) | KDM4EALDH1A1CES2NPSR1CYP2C19 | |
| SCHEMBL20324928 | 0.81 | CES2 (0.41) | KDM4EALDH1A1CES2NPSR1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200038513-A1 | MODULATORS OF FAK PROTEOLYSIS AND ASSOCIATED METHODS OF USE | YALE UNIVERSITY | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200038513-A1 | MODULATORS OF FAK PROTEOLYSIS AND ASSOCIATED METHODS OF USE | PTK2, CTTN, CRBN | KDM4E 3237/4885ALDH1A1 3692/4885CES2 3422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.