Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | CBFB | Q13951 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21666183 | 0.90 | KDM4E (0.58) | STAT3FGFR1PDGFRBKDRKDM4E | |
| SCHEMBL23293905 | 0.81 | STAT3 (0.49) | STAT3CBFBFGFR1FLT1PDGFRB | |
| SCHEMBL18643544 | 0.81 | STAT3 (0.61) | STAT3FGFR1FLT1PDGFRBKDR | |
| SCHEMBL14877387 | 0.80 | FGFR1 (0.53) | STAT3CBFBFGFR1FLT1PDGFRB | |
| SCHEMBL21524689 | 0.75 | STAT3 (0.53) | STAT3FGFR1FLT1PDGFRBKDR | |
| SCHEMBL14877401 | 0.75 | PDGFRB (0.57) | STAT3CBFBFGFR1FLT1PDGFRB | |
| SCHEMBL14877218 | 0.74 | FGFR1 (0.50) | STAT3CBFBFGFR1FLT1PDGFRB | |
| SCHEMBL2913480 | 0.74 | NPC1 (0.64) | KDM4EALDH1A1MAPTHPGDTNKS | |
| SCHEMBL120730 | 0.73 | KDM4E (0.49) | STAT3KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL30434730 | 0.73 | KDM4E (0.49) | STAT3KDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020021064-A1 | SUBSTITUTED QUINAZOLINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4 | DOMAIN THERAPEUTICS (FR) | 2020-01-30 | — | — | WO | disclosed |