Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.48 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21666182 | 0.90 | STAT3 (0.52) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL20509747 | 0.79 | KDM4E (0.59) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL14877136 | 0.78 | KDM4E (0.56) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL14877439 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL2913480 | 0.76 | NPC1 (0.64) | KDM4EALDH1A1MAPTHPGDTNKS | |
| SCHEMBL23293858 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL25150681 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL14877017 | 0.73 | KDM4E (0.53) | KDM4EALDH1A1MAPTMEN1POLB | |
| Hydrochloric Acid SCHEMBL23293893 | 0.73 | KDM4E (0.44) | KDM4EALDH1A1MAPTMEN1POLB | |
| Hydrochloric Acid SCHEMBL29800843 | 0.73 | KDM4E (0.44) | KDM4EALDH1A1MAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020021064-A1 | SUBSTITUTED QUINAZOLINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4 | DOMAIN THERAPEUTICS (FR) | 2020-01-30 | — | — | WO | disclosed |