Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15225875 | 0.94 | EPHX1 (0.76) | EPHX1HPGDMAPK1EPHX2KMT2A | |
| SCHEMBL1609547 | 0.94 | EPHX1 (0.59) | EPHX1HPGDMAPK1EPHX2KMT2A | |
| SCHEMBL3771276 | 0.94 | EPHX1 (0.59) | EPHX1HPGDMAPK1EPHX2KMT2A | |
| SCHEMBL609758 | 0.93 | EPHX1 (0.63) | EPHX1HPGDMAPK1EPHX2KMT2A | |
| SCHEMBL29979852 | 0.93 | EPHX1 (0.63) | EPHX1HPGDMAPK1EPHX2KMT2A | |
| SCHEMBL1437840 | 0.93 | EPHX1 (0.74) | EPHX1HPGDMAPK1EPHX2KMT2A | |
| Bicarbonate SCHEMBL9234681 | 0.92 | EPHX1 (0.72) | EPHX1HPGDMAPK1EPHX2KMT2A | |
| SCHEMBL23019780 | 0.89 | EPHX1 (0.64) | EPHX1HPGDEPHX2KMT2AMEN1 | |
| SCHEMBL21324542 | 0.89 | EPHX1 (0.64) | EPHX1HPGDEPHX2KMT2AMEN1 | |
| SCHEMBL14258606 | 0.89 | ALDH1A1 (0.57) | EPHX1HPGDMAPK1EPHX2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |