Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | USP1 | O94782 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667184 | 0.82 | MEN1 (0.43) | LMNAMEN1KMT2ACYP3A4CYP2B6 | |
| SCHEMBL16321805 | 0.80 | CYP3A4 (0.63) | LMNACYP3A4CYP2B6USP1KDM5B | |
| SCHEMBL16321803 | 0.80 | CYP3A4 (0.63) | LMNACYP3A4CYP2B6USP1KDM5B | |
| SCHEMBL21667347 | 0.79 | CYP3A4 (0.50) | LMNAMEN1KMT2ACYP3A4CYP2B6 | |
| SCHEMBL21667306 | 0.79 | CYP3A4 (0.50) | LMNAMEN1KMT2ACYP3A4CYP2B6 | |
| SCHEMBL20716038 | 0.79 | CYP3A4 (0.61) | LMNAMEN1KMT2ACYP3A4CYP2B6 | |
| SCHEMBL21667374 | 0.78 | CYP3A4 (0.52) | LMNAMEN1KMT2ACYP3A4CYP2B6 | |
| SCHEMBL21667176 | 0.78 | CYP3A4 (0.49) | LMNAMEN1KMT2ACYP3A4CYP2B6 | |
| SCHEMBL21667309 | 0.78 | CYP3A4 (0.49) | LMNAMEN1KMT2ACYP3A4CYP2B6 | |
| SCHEMBL21667270 | 0.77 | KMT2A (0.64) | MEN1KMT2ACYP3A4CYP2B6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |