Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.45 |
| ▸ | TYMP | P19971 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | G6PD | P11413 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667334 | 0.92 | SMN1; SMN2 (0.60) | SMN1; SMN2TP53CYP3A4CYP2B6GPR84 | |
| SCHEMBL20716038 | 0.86 | CYP3A4 (0.61) | SMN1; SMN2TP53CYP3A4CYP2B6GPR84 | |
| SCHEMBL16321231 | 0.82 | CYP3A4 (0.63) | SMN1; SMN2TP53CYP3A4CYP2B6MEN1 | |
| SCHEMBL16321233 | 0.82 | CYP3A4 (0.63) | SMN1; SMN2TP53CYP3A4CYP2B6MEN1 | |
| SCHEMBL16321942 | 0.79 | CYP3A4 (0.66) | SMN1; SMN2TP53CYP3A4CYP2B6MEN1 | |
| SCHEMBL16321940 | 0.79 | CYP3A4 (0.66) | SMN1; SMN2TP53CYP3A4CYP2B6MEN1 | |
| SCHEMBL21667347 | 0.77 | CYP3A4 (0.50) | SMN1; SMN2TP53CYP3A4CYP2B6MEN1 | |
| SCHEMBL21667306 | 0.77 | CYP3A4 (0.50) | SMN1; SMN2TP53CYP3A4CYP2B6GPR84 | |
| SCHEMBL21667198 | 0.77 | CYP3A4 (0.50) | SMN1; SMN2TP53CYP3A4CYP2B6MEN1 | |
| SCHEMBL21667374 | 0.76 | CYP3A4 (0.52) | SMN1; SMN2TP53CYP3A4CYP2B6GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117897155-A | Use of PPARgamma agonists or MPC inhibitors for the treatment of primary, congenital diseases of the heart muscle (cardiomyopathy) | 预防治疗有限公司 | 2024-04-16 | — | — | CN | disclosed |
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |