Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667283 | 0.88 | KMT2A (0.50) | GPR84TP53SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL21667382 | 0.86 | ADORA1 (0.49) | GPR84TP53SMN1; SMN2ADORA1KMT2A | |
| SCHEMBL21667187 | 0.86 | SMN1; SMN2 (0.54) | TP53SMN1; SMN2ADORA2AADORA2BADORA1 | |
| SCHEMBL21667344 | 0.85 | EGFR (0.54) | TP53SMN1; SMN2ADORA2AADORA2BADORA1 | |
| SCHEMBL21667329 | 0.83 | GRM2 (0.52) | SMN1; SMN2KMT2AMEN1HSD17B10DAO | |
| SCHEMBL21667340 | 0.81 | ADORA2A (0.45) | GPR84SMN1; SMN2ADORA2AADORA2BADORA1 | |
| SCHEMBL21667176 | 0.81 | CYP3A4 (0.49) | GPR84TP53SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL16320817 | 0.78 | HTT (0.53) | KDM1ASMN1; SMN2ADORA2AADORA2BADORA1 | |
| SCHEMBL16320816 | 0.78 | HTT (0.53) | KDM1ASMN1; SMN2ADORA2AADORA2BADORA1 | |
| SCHEMBL21667387 | 0.76 | PGR (0.47) | GPR84TP53SMN1; SMN2ADORA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |