Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 11/20 | 0.65 |
| ▸ | MMP1 | P03956 | 3/20 | 0.56 |
| ▸ | FCER2 | P06734 | 3/20 | 0.56 |
| ▸ | KLK1 | P06870 | 4/20 | 0.48 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | CPA1 | P15085 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14485419 | 1.00 | KLKB1 (0.65) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL14485397 | 0.94 | KLKB1 (0.64) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL14485393 | 0.94 | KLKB1 (0.64) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL15901681 | 0.91 | KLKB1 (0.69) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL21669870 | 0.91 | KLKB1 (0.69) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL14485279 | 0.91 | KLKB1 (0.69) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL15900864 | 0.90 | KLKB1 (0.64) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL15901716 | 0.90 | KLKB1 (0.64) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL14485759 | 0.90 | KLKB1 (0.64) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL14486054 | 0.90 | KLKB1 (0.64) | KLKB1MMP1FCER2KLK1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032018-A | Pharmaceutical composition | 卡尔维斯塔制药有限公司 | 2020-04-17 | — | — | CN | claimed |
| EP-2729443-B3 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-02-12 | — | — | EP | claimed |
| CN-103687846-B | Benzyl amine derivative as inhibitors of plasma kallikrein | 卡尔维斯塔制药有限公司 | 2016-06-22 | — | — | CN | claimed |
| CN-111032018-A | Pharmaceutical composition | 卡尔维斯塔制药有限公司 | 2020-04-17 | — | — | CN | disclosed |
| CN-103687846-B | Benzyl amine derivative as inhibitors of plasma kallikrein | 卡尔维斯塔制药有限公司 | 2016-06-22 | — | — | CN | disclosed |