Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 12/20 | 0.69 |
| ▸ | MMP1 | P03956 | 3/20 | 0.59 |
| ▸ | FCER2 | P06734 | 3/20 | 0.59 |
| ▸ | KLK1 | P06870 | 4/20 | 0.51 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
| ▸ | MME | P08473 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | CPA1 | P15085 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15901681 | 1.00 | KLKB1 (0.69) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL14485279 | 1.00 | KLKB1 (0.69) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL14485875 | 0.93 | KLKB1 (0.67) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL21669867 | 0.91 | KLKB1 (0.65) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL14485419 | 0.91 | KLKB1 (0.65) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL14485397 | 0.90 | KLKB1 (0.64) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL14485759 | 0.90 | KLKB1 (0.64) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL14485393 | 0.90 | KLKB1 (0.64) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL15901716 | 0.90 | KLKB1 (0.64) | KLKB1MMP1FCER2KLK1REN | |
| SCHEMBL15900864 | 0.90 | KLKB1 (0.64) | KLKB1MMP1FCER2KLK1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729443-B3 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-02-12 | — | — | EP | disclosed |