Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 3/20 | 0.51 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29394299 | 1.00 | FGFR4 (0.51) | FGFR4HSF1BRD4MAPTRPS6KB2 | |
| SCHEMBL29393230 | 0.78 | FGFR4 (0.47) | FGFR4HSF1BRD4MAPTRPS6KB2 | |
| SCHEMBL21672282 | 0.78 | FGFR4 (0.47) | FGFR4HSF1BRD4MAPTRPS6KB2 | |
| SCHEMBL16739538 | 0.77 | FGFR4 (0.65) | FGFR4MAPTHTTHPGDALDH1A1 | |
| SCHEMBL9984822 | 0.74 | FGFR4 (0.52) | FGFR4HSF1BRD4MAPTRPS6KB2 | |
| SCHEMBL6789738 | 0.74 | HSF1 (0.72) | FGFR4HSF1MAPTPOLB | |
| SCHEMBL29393275 | 0.73 | FGFR4 (0.54) | FGFR4HSF1MAPTPOLBALDH1A1 | |
| SCHEMBL29392511 | 0.73 | FGFR4 (0.54) | FGFR4HSF1BRD4MAPTRPS6KB2 | |
| SCHEMBL14762497 | 0.73 | FGFR4 (0.51) | FGFR4MAPTRPS6KB2HTTNPSR1 | |
| SCHEMBL12705359 | 0.72 | FGFR4 (0.52) | FGFR4BRD4MAPTRPS6KB2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200039989-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200039989-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | CLK2, CLK1, CLK3 | FGFR4 1415/4885HSF1 2855/4885BRD4 356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.