Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29535826 | 0.88 | MAPT (0.54) | FGFR4MAPTHTTL3MBTL1PIN1 | |
| SCHEMBL22719050 | 0.88 | MAPT (0.54) | FGFR4MAPTHTTL3MBTL1PIN1 | |
| SCHEMBL9984336 | 0.87 | MAPT (0.52) | FGFR4MAPTHTTPIN1MEN1 | |
| SCHEMBL9984006 | 0.85 | MAPT (0.55) | FGFR4MAPTHTTALDH1A1RAB9A | |
| SCHEMBL718271 | 0.85 | MAPT (0.51) | FGFR4MAPTHTTL3MBTL1ALDH1A1 | |
| SCHEMBL1600402 | 0.85 | PIN1 (0.65) | FGFR4MAPTHTTL3MBTL1ALDH1A1 | |
| SCHEMBL16739538 | 0.85 | FGFR4 (0.65) | FGFR4MAPTHTTALDH1A1PIN1 | |
| SCHEMBL9984822 | 0.85 | FGFR4 (0.52) | FGFR4MAPTHTTALDH1A1PIN1 | |
| SCHEMBL29392511 | 0.83 | FGFR4 (0.54) | FGFR4MAPTHTTALDH1A1RAB9A | |
| SCHEMBL29393275 | 0.83 | FGFR4 (0.54) | FGFR4MAPTALDH1A1PIN1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919617-B2 | Cytokine inhibitors | iTherX Pharmaceuticals Inc. (US) | 2011-04-05 | — | — | US | disclosed |
| US-20100093734-A1 | CYTOKINE INHIBITORS | ITHERX PHARMACEUTICALS, INC. (US) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093734-A1 | CYTOKINE INHIBITORS | TNF, IL1RN, IL1A | FGFR4 767/4885MAPT 3744/4885HTT 3178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.