Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | TSHR | P16473 | 6/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16721789 | 1.00 | BRD4 (0.58) | BRD4NPC1RAB9AALDH1A1TSHR | |
| SCHEMBL16721360 | 0.84 | BRD4 (0.54) | BRD4NPC1RAB9AALDH1A1TSHR | |
| SCHEMBL21675311 | 0.84 | BRD4 (0.54) | BRD4NPC1RAB9AALDH1A1TSHR | |
| SCHEMBL21674581 | 0.82 | BRD4 (0.58) | BRD4NPC1RAB9ATSHRHPGD | |
| SCHEMBL16721860 | 0.82 | BRD4 (0.58) | BRD4NPC1RAB9ATSHRHPGD | |
| SCHEMBL16721973 | 0.81 | BRD4 (0.66) | BRD4ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL16721423 | 0.81 | BRD4 (0.52) | BRD4NPC1RAB9AALDH1A1TSHR | |
| SCHEMBL21675133 | 0.79 | BRD4 (0.60) | BRD4MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL16721785 | 0.79 | BRD4 (0.60) | BRD4MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL21675261 | 0.79 | BRD4 (0.60) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071205-B1 | BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | FORMA THERAPEUTICS INC (US) | 2020-02-05 | — | — | EP | disclosed |