Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ipratropium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.60 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ipratropium SCHEMBL29400593 | 1.00 | CHRM2 (0.60) | CHRM2CHRM5MEN1CHRM4CHRM1 | |
| Ipratropium SCHEMBL27974717 | 1.00 | CHRM2 (0.60) | CHRM2CHRM5MEN1CHRM4CHRM1 | |
| Ipratropium SCHEMBL117888 | 0.99 | CHRM2 (0.60) | CHRM2CHRM5MEN1CHRM4CHRM1 | |
| Ipratropium SCHEMBL2166848 | 0.97 | CHRM2 (0.63) | CHRM2CHRM5MEN1CHRM4CHRM1 | |
| Ipratropium SCHEMBL4231044 | 0.97 | CHRM2 (0.63) | CHRM2CHRM5MEN1CHRM4CHRM1 | |
| Ipratropium SCHEMBL28250222 | 0.96 | CHRM2 (0.65) | CHRM2CHRM5MEN1CHRM4CHRM1 | |
| Ipratropium SCHEMBL28223580 | 0.96 | CHRM2 (0.64) | CHRM2CHRM5MEN1CHRM4CHRM1 | |
| Ipratropium SCHEMBL2169666 | 0.96 | CHRM2 (0.64) | CHRM2CHRM5MEN1CHRM4CHRM1 | |
| Ipratropium SCHEMBL28250221 | 0.96 | CHRM2 (0.63) | CHRM2CHRM5MEN1CHRM4CHRM1 | |
| Atropine SCHEMBL5079571 | 0.86 | MAPT (0.64) | CHRM2CHRM5MEN1CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9011923-B2 | Suspension formulations | INNOVATA BIOMED LIMITED (GB) | 2015-04-21 | — | — | US | disclosed |
| US-20130142879-A1 | SUSPENSION FORMULATIONS | INNOVATA BIOMED LIMITED (GB) | 2013-06-06 | — | — | US | disclosed |
| US-20110182997-A1 | SUSPENSION FORMULATIONS | VECTURA LIMITED (GB) | 2011-07-28 | — | — | US | disclosed |
| EP-2249807-A2 | SUSPENSION FORMULATIONS | Vectura Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009095681-A2 | SUSPENSION FORMULATIONS | VECTURA LIMITED (GB) | 2009-08-06 | — | — | WO | disclosed |
| US-20020081266-A1 | Spray dried powders for pulmonary or nasal administration | NORTON HEALTHCARE LTD. | 2002-06-27 | — | — | US | disclosed |