Atropine

Atropine

SCHEMBL5079571

CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2.O=S(=O)(O)O.O=S(=O)(O)O

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CHRM1CHRM2CHRM3

The experimentally established mechanism targets of Atropine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 4/20 0.58
CHRM1 known ✓ P11229 4/20 0.58
CHRM3 known ✓ P20309 4/20 0.58
MAPT P10636 1/20 0.64
ALDH1A1 P00352 1/20 0.63
CHRM5 P08912 4/20 0.58
LMNA P02545 3/20 0.58
CHRM4 P08173 3/20 0.58
HTR2C P28335 2/20 0.58
NFKB1 P19838 2/20 0.58
BLM P54132 2/20 0.58
KDM4E B2RXH2 1/20 0.58
MEN1 O00255 1/20 0.58
POLB P06746 1/20 0.58
ADRA2C P18825 1/20 0.58
ADRA1A P35348 1/20 0.58
HRH1 P35367 1/20 0.58
KMT2A Q03164 1/20 0.58
PMP22 Q01453 1/20 0.58
SLC22A1 O15245 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Atropine SCHEMBL5079572 1.00 MAPT (0.64) MAPTALDH1A1CHRM2CHRM5CHRM1
Ipratropium SCHEMBL117888 0.87 CHRM2 (0.60) MAPTALDH1A1CHRM2CHRM5CHRM1
Ipratropium SCHEMBL2167530 0.86 CHRM2 (0.60) MAPTALDH1A1CHRM2CHRM5CHRM1
Ipratropium SCHEMBL27974717 0.86 CHRM2 (0.60) MAPTALDH1A1CHRM2CHRM5CHRM1
Ipratropium SCHEMBL29400593 0.86 CHRM2 (0.60) MAPTALDH1A1CHRM2CHRM5CHRM1
Ipratropium SCHEMBL28223580 0.83 CHRM2 (0.64) CHRM2CHRM5CHRM1CHRM3CHRM4
Ipratropium SCHEMBL2169666 0.83 CHRM2 (0.64) CHRM2CHRM5CHRM1CHRM3CHRM4
Ipratropium SCHEMBL2166848 0.83 CHRM2 (0.63) CHRM2CHRM5CHRM1CHRM3CHRM4
Ipratropium SCHEMBL4231044 0.83 CHRM2 (0.63) CHRM2CHRM5CHRM1CHRM3CHRM4
Ipratropium SCHEMBL28250221 0.83 CHRM2 (0.63) CHRM2CHRM5CHRM1CHRM3CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080199623-A1 ANTIMICROBIAL COMPOSITIONS CONTAINING COLLOIDS OF OLIGODYNAMIC MATERIALS C.R. BARD. INC. (US) 2008-08-21 US disclosed