Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.32 |
| ▸ | SAT1 | P21673 | 1/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.31 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17919936 | 0.89 | SIGMAR1 (0.50) | SIGMAR1MAPTCARM1PRMT6SAT1 | |
| SCHEMBL919372 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL14744246 | 0.87 | — | — | |
| SCHEMBL13444766 | 0.86 | SIGMAR1 (0.55) | SIGMAR1MAPTCARM1PRMT6SAT1 | |
| SCHEMBL26573065 | 0.81 | SIGMAR1 (0.32) | SIGMAR1 | |
| SCHEMBL20792495 | 0.80 | MAPT (0.38) | SIGMAR1MAPTHTR2AHRH1 | |
| SCHEMBL25927003 | 0.80 | CARM1 (0.45) | SIGMAR1MAPTCARM1PRMT6PRMT1 | |
| SCHEMBL17919937 | 0.80 | SIGMAR1 (0.48) | SIGMAR1MAPTCARM1PRMT6SAT1 | |
| SCHEMBL1680312 | 0.79 | — | — | |
| SCHEMBL919693 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3693022-A2 | COX-2-TARGETING, PLATINUM-CONTAINING CONJUGATES AND THEIR USE IN THE TREATMENT OF TUMORS AND CANCERS | Reiley Pharmaceuticals, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-3242688-B1 | COX-2-TARGETING, PLATINUM-CONTAINING CONJUGATES AND THEIR USE IN THE TREATMENT OF TUMORS AND CANCERS | REILEY PHARMACEUTICALS INC (US) | 2020-01-29 | — | — | EP | disclosed |