Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BCL6 | P41182 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632859 | 0.78 | ROCK1 (0.45) | MEN1KMT2ANPC1RAB9AROCK1 | |
| SCHEMBL21642888 | 0.78 | ROCK1 (0.45) | MEN1KMT2ANPC1RAB9AROCK1 | |
| SCHEMBL2228112 | 0.78 | AURKA (0.59) | MEN1KMT2ANPC1RAB9AROCK1 | |
| SCHEMBL18387036 | 0.76 | MAPK10 (0.57) | MEN1KMT2AMAPK10ROCK1EGFR | |
| SCHEMBL1163079 | 0.73 | KMT2A (0.50) | MEN1KMT2ANPC1RAB9AROCK1 | |
| SCHEMBL19709445 | 0.72 | KMT2A (0.54) | MEN1KMT2AMAPK10NPC1BCL6 | |
| SCHEMBL2779777 | 0.72 | MEN1 (0.50) | MEN1KMT2AMAPK10NPC1RAB9A | |
| SCHEMBL1172331 | 0.72 | EPHB4 (0.57) | — | |
| SCHEMBL5914036 | 0.71 | MEN1 (0.51) | MEN1KMT2ANPC1RAB9AROCK1 | |
| SCHEMBL4630896 | 0.71 | CCR4 (0.39) | MEN1KMT2ANPC1RAB9APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10781201-B2 | Benzimidazole derivative having JNK inhibitory activity and use thereof | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS (KR) | 2020-09-22 | — | — | US | disclosed |
| US-20200039959-A1 | NOVEL BENZIMIDAZOLE DERIVATIVE HAVING JNK INHIBITORY ACTIVITY AND USE THEREOF | INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS (KR) | 2020-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200039959-A1 | NOVEL BENZIMIDAZOLE DERIVATIVE HAVING JNK INHIBITORY ACTIVITY AND USE THEREOF | MAPKAPK3, MAPK3, MAP3K3 | MEN1 4509/4885KMT2A 2497/4885MAPK10 50/4885 |
| US-10781201-B2 | Benzimidazole derivative having JNK inhibitory activity and use thereof | MAPKAPK3, MAPK3, MAP3K3 | MEN1 4421/4885KMT2A 2317/4885MAPK10 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.