Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 5/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15602773 | 0.82 | CCR4 (0.48) | CCR4CDC7KMT2ASYKRAF1 | |
| SCHEMBL1171821 | 0.81 | RECQL (0.42) | PPARGPPARAMEN1NPC1RAB9A | |
| SCHEMBL1172331 | 0.74 | EPHB4 (0.57) | RAF1BRAF | |
| SCHEMBL21676894 | 0.71 | MEN1 (0.62) | PPARGPPARAMEN1NPC1RAB9A | |
| SCHEMBL15395341 | 0.70 | SYK (0.61) | SYKTRPV1 | |
| SCHEMBL8312915 | 0.69 | CCR4 (0.55) | CCR4MEN1KMT2ARAF1BRAF | |
| SCHEMBL31130330 | 0.68 | CCR4 (0.50) | CCR4SYKRAF1BRAFTRPV1 | |
| SCHEMBL13707016 | 0.68 | CCR4 (0.53) | CCR4KMT2ARAF1BRAFTRPV1 | |
| SCHEMBL2228112 | 0.67 | AURKA (0.59) | MEN1NPC1RAB9AKMT2ABRAF | |
| SCHEMBL12650371 | 0.67 | MAPK14 (0.40) | PPARGPPARAMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981856-A2 | PYRIMIDINE DERIVATIVES | AstraZeneca AB (SE) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085833-A2 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |