Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.47 |
| ▸ | JAK2 | O60674 | 5/20 | 0.46 |
| ▸ | CLK1 | P49759 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | SIK1 | P57059 | 2/20 | 0.43 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.43 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 5/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15805375 | 0.93 | JAK2 (0.45) | AXLJAK2CLK1DYRK1ASIK1 | |
| SCHEMBL15805447 | 0.84 | JAK2 (0.49) | AXLJAK2CLK1DYRK1AJAK1 | |
| SCHEMBL21677036 | 0.79 | CLK1 (0.45) | AXLJAK2CLK1DYRK1ABRD4 | |
| SCHEMBL15805363 | 0.79 | AXL (0.47) | AXLJAK2CLK1DYRK1ASIK1 | |
| SCHEMBL12965679 | 0.75 | AXL (0.52) | AXLJAK2SIK1SIK2SIK3 | |
| SCHEMBL17640327 | 0.72 | JAK2 (0.49) | AXLJAK2SIK1SIK2SIK3 | |
| SCHEMBL18921933 | 0.70 | AXL (0.52) | AXLJAK2BRD4JAK1JAK3 | |
| SCHEMBL15805392 | 0.69 | CLK1 (0.46) | JAK2CLK1DYRK1AJAK3BTK | |
| SCHEMBL4484592 | 0.67 | SIK1 (0.66) | AXLJAK2SIK1SIK2SIK3 | |
| SCHEMBL17640273 | 0.67 | AXL (0.48) | AXLJAK2JAK3BTKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931722-B1 | SUBSTITUTED 1H-PYRROLO [2,3-B]PYRIDINE AND 1H-PYRAZOLO [3, 4-B]PYRIDINE DERIVATIVES AS SALT INDUCIBLE KINASE 2 (SIK2) INHIBITORS | ARRIEN PHARMACEUTICALS LLC (US) | 2020-02-05 | — | — | EP | disclosed |