Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18921934 | 0.78 | AXL (0.45) | AXLJAK2FLT3JAK3 | |
| SCHEMBL12965947 | 0.78 | JAK2 (0.46) | AXLJAK2PDE7AFLT3JAK3 | |
| SCHEMBL12965679 | 0.78 | AXL (0.52) | AXLJAK2PDE7AFLT3KDM4E | |
| SCHEMBL18921936 | 0.71 | MAP4K1 (0.51) | — | |
| SCHEMBL29469944 | 0.70 | AXL (0.55) | AXLJAK2FLT3KDM4EBRD4 | |
| SCHEMBL21677035 | 0.70 | AXL (0.47) | AXLJAK2FLT3BRD4JAK3 | |
| SCHEMBL15805375 | 0.69 | JAK2 (0.45) | AXLJAK2FLT3KDM4EBRD4 | |
| SCHEMBL15805447 | 0.68 | JAK2 (0.49) | AXLJAK2FLT3JAK3BTK | |
| SCHEMBL21677036 | 0.68 | CLK1 (0.45) | AXLJAK2FLT3KDM4EBRD4 | |
| SCHEMBL15805363 | 0.68 | AXL (0.47) | AXLJAK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9962382-B2 | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2018-05-08 | — | — | US | disclosed |
| US-9669028-B2 | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors | ARRIEN PHARMACEUTICALS LLC (US) | 2017-06-06 | — | — | US | disclosed |