Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 10/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 7/20 | 0.43 |
| ▸ | IL2 | P60568 | 3/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15805266 | 0.94 | MAP4K1 (0.49) | MAP4K1TNIKMAP3K11IL2SGK1 | |
| SCHEMBL21676912 | 0.79 | TNIK (0.46) | TNIKMET | |
| SCHEMBL19860025 | 0.76 | SIK1 (0.46) | MAP4K1TNIKMAP3K11 | |
| SCHEMBL15799697 | 0.76 | TNIK (0.52) | MAP4K1TNIKIL2MET | |
| SCHEMBL21677011 | 0.75 | MAP4K1 (0.41) | MAP4K1TNIKMAP3K11IL2 | |
| SCHEMBL15805270 | 0.74 | SIK1 (0.59) | MAP4K1TNIKMAP3K11IL2 | |
| SCHEMBL15799549 | 0.74 | TNIK (0.49) | TNIKMET | |
| SCHEMBL15799255 | 0.73 | TNIK (0.47) | TNIKMET | |
| SCHEMBL15799597 | 0.71 | TNIK (0.45) | TNIKMET | |
| SCHEMBL15799554 | 0.68 | PAK1 (0.61) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931722-B1 | SUBSTITUTED 1H-PYRROLO [2,3-B]PYRIDINE AND 1H-PYRAZOLO [3, 4-B]PYRIDINE DERIVATIVES AS SALT INDUCIBLE KINASE 2 (SIK2) INHIBITORS | ARRIEN PHARMACEUTICALS LLC (US) | 2020-02-05 | — | — | EP | disclosed |