⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19481696 | 0.86 | GAA (0.40) | — | |
| SCHEMBL19486447 | 0.84 | — | — | |
| SCHEMBL30958498 | 0.83 | — | — | |
| SCHEMBL19481695 | 0.82 | CTSL (0.40) | — | |
| SCHEMBL19481693 | 0.82 | CTSL (0.40) | — | |
| SCHEMBL21679774 | 0.81 | KHK (0.43) | — | |
| SCHEMBL25795817 | 0.80 | — | — | |
| SCHEMBL19459241 | 0.79 | — | — | |
| SCHEMBL19459073 | 0.79 | — | — | |
| SCHEMBL19459074 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10669277-B2 | Inhibitors of activin receptor-like kinase | BLUEPRINT MEDICINES CORPORATION (US) | 2020-06-02 | — | — | US | disclosed |
| US-20200031830-A1 | INHIBITORS OF ACTIVIN RECEPTOR-LIKE KINASE | BLUEPRINT MEDICINES CORPORATION (US) | 2020-01-30 | — | — | US | disclosed |