Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | BTK | Q06187 | 10/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21678365 | 1.00 | RPS6KB1 (0.53) | RPS6KB1AURKABTKPDPK1JAK3 | |
| SCHEMBL21704900 | 0.89 | RPS6KB1 (0.52) | RPS6KB1AURKABTKPDPK1JAK3 | |
| SCHEMBL21704901 | 0.89 | RPS6KB1 (0.52) | RPS6KB1AURKABTKPDPK1JAK3 | |
| Hydrochloric Acid SCHEMBL21678642 | 0.88 | RPS6KB1 (0.51) | RPS6KB1AURKABTKPDPK1JAK3 | |
| Hydrochloric Acid SCHEMBL21678645 | 0.88 | RPS6KB1 (0.51) | RPS6KB1AURKABTKPDPK1JAK3 | |
| SCHEMBL21704944 | 0.88 | RPS6KB1 (0.51) | RPS6KB1AURKABTKPDPK1JAK3 | |
| SCHEMBL21705069 | 0.88 | RPS6KB1 (0.51) | RPS6KB1AURKABTKPDPK1JAK3 | |
| Hydrochloric Acid SCHEMBL21678388 | 0.87 | RPS6KB1 (0.50) | RPS6KB1AURKABTKPDPK1JAK3 | |
| Hydrochloric Acid SCHEMBL21678391 | 0.87 | RPS6KB1 (0.50) | RPS6KB1AURKABTKPDPK1JAK3 | |
| SCHEMBL16765057 | 0.87 | JAK3 (0.64) | RPS6KB1AURKABTKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240132505-A1 | PYRROLOPYRIMIDINE ITK INHIBITORS | ACLARIS THERAPEUTICS, INC. | 2024-04-25 | — | — | US | disclosed |
| US-11820775-B2 | Pyrrolopyrimidine ITK inhibitors | ACLARIS THERAPEUTICS, INC. (US) | 2023-11-21 | — | — | US | disclosed |
| US-11021482-B2 | Pyrrolopyrimidine ITK inhibitors | Adaris Therapeutics, Inc. (US) | 2021-06-01 | — | — | US | disclosed |
| CN-112823005-A | Pyrrolopyrimidine ITK inhibitors | 阿克拉瑞斯治疗股份有限公司 | 2021-05-18 | — | — | CN | disclosed |
| US-20200048262-A1 | PYRROLOPYRIMIDINE ITK INHIBITORS | ACLARIS THERAPEUTICS, INC. | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048262-A1 | PYRROLOPYRIMIDINE ITK INHIBITORS | ITK, PDXK, DMPK | RPS6KB1 157/4885AURKA 1216/4885BTK 558/4885 |
| US-20240132505-A1 | PYRROLOPYRIMIDINE ITK INHIBITORS | ITK, PDXK, DMPK | RPS6KB1 157/4885AURKA 1216/4885BTK 558/4885 |
| US-11021482-B2 | Pyrrolopyrimidine ITK inhibitors | ITK, PDXK, DMPK | RPS6KB1 157/4885AURKA 1216/4885BTK 558/4885 |
| US-11820775-B2 | Pyrrolopyrimidine ITK inhibitors | ITK, PDXK, DMPK | RPS6KB1 157/4885AURKA 1216/4885BTK 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.