Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 1.00 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.65 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.49 |
| ▸ | HTR3B | O95264 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTR3A | P46098 | 2/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3781500 | 0.98 | HRH3 (0.97) | HRH3HRH4PLD1CYP1A2HSD17B10 | |
| Hydrochloric Acid SCHEMBL26600058 | 0.98 | HRH3 (0.97) | HRH3HRH4PLD1CYP1A2HSD17B10 | |
| SCHEMBL13018668 | 0.94 | HRH3 (0.88) | HRH3HRH4PLD1CYP1A2HSD17B10 | |
| SCHEMBL30411053 | 0.85 | HRH3 (0.73) | HRH3HRH4PLD1CYP1A2HSD17B10 | |
| SCHEMBL13018670 | 0.84 | HRH3 (0.76) | HRH3HRH4CYP1A2HSD17B10CYP2C9 | |
| SCHEMBL17626748 | 0.83 | HRH3 (0.71) | HRH3HRH4ROCK1 | |
| SCHEMBL14880196 | 0.83 | HRH3 (0.71) | HRH3HRH4HSD17B10USP2HTT | |
| SCHEMBL10932400 | 0.81 | HRH3 (0.69) | HRH3HRH4HSD17B10USP2HTT | |
| Bromide SCHEMBL20445910 | 0.81 | HRH3 (0.69) | HRH3HRH4HSD17B10USP2HTT | |
| SCHEMBL13018665 | 0.79 | HRH3 (0.65) | HRH3HRH4CYP1A2HSD17B10CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | claimed |
| JP-58046084-A | — | — | None | — | — | JP | disclosed |
| US-20230340011-A1 | STEROIDAL COMPOSITIONS AND METHODS OF TREATING LIPOGENIC CANCERS | Asteroid Therapeutics | 2023-10-26 | — | — | US | disclosed |
| US-20230340011-A1 | STEROIDAL COMPOSITIONS AND METHODS OF TREATING LIPOGENIC CANCERS | Asteroid Therapeutics | 2023-10-26 | — | — | US | disclosed |
| WO-2023125908-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |
| EP-2773632-B1 | 8-FLUOROPHTHALAZIN-1(2H)-ONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY | HOFFMANN LA ROCHE (CH) | 2017-04-12 | — | — | EP | disclosed |
| US-9023834-B2 | Lyophilization formulation | TAIGEN BIOTECHNOLOGY CO., LTD. (TW) | 2015-05-05 | — | — | US | disclosed |
| CN-104203937-A | 8-fluorophthalazin-1 (2h) - one compounds as inhibitors of btk activity | HOFFMANN LA ROCHE | 2014-12-10 | — | — | CN | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |
| US-7985745-B2 | Including inflammatory pain, post surgical pain, and neuropathic pain; administering a histamine H4 receptor ligand alone or in combination with a histamine H1, H2, or H3 receptor antagonist or an enzyme inhibitor | ABBOTT LABORATORIES (US) | 2011-07-26 | — | — | US | disclosed |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
| WO-2010056847-A2 | LYOPHILIZATION FORMULATION | TAIGEN BIOTECHNOLOGY CO., LTD. (TW) | 2010-05-20 | — | — | WO | disclosed |
| US-20100120719-A1 | LYOPHILIZATION FORMULATION | TAIGEN BIOTECHNOLOGY CO., LTD. (TW) | 2010-05-13 | — | — | US | disclosed |
| US-20080194538-A1 | Method for Pain Treatment | ABBVIE INC. | 2008-08-14 | — | — | US | disclosed |
| WO-2008060766-A2 | HISTAMINE H4 RECEPTOR LIGANDS FOR USE IN PAIN TREATMENT | ABBOTT LABORATORIES (US) | 2008-05-22 | — | — | WO | disclosed |
| EP-0644885-A1 | NOVEL BIOLOGICALLY ACTIVE EBURNAMENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | RICHETER GEDEON VEGYESZETI GYAR RT. (HU) | 1995-03-29 | — | — | EP | disclosed |
| JP-S5846084-A | PYRIMIDINOAMINOMETHYLENEMALONIC ACID ESTER AND ITS PREPARATION | MITSUI PETROCHEM IND LTD | 1983-03-17 | — | — | JP | disclosed |
| US-4166852-A | ANALGESICS, ANTISEROTONINE AGENTS, PSYCHOTROPES | PRODUITS CHIMIQUES UGINE KUHLMANN (FR) | 1979-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230340011-A1 | STEROIDAL COMPOSITIONS AND METHODS OF TREATING LIPOGENIC CANCERS | SREBF1, SREBF2, NR1H3 | HRH3 4494/4885HRH4 4558/4885PLD1 1658/4885 |
| US-20080194538-A1 | Method for Pain Treatment | HRH4, HRH3, HRH2 | HRH3 2/4885HRH4 1/4885PLD1 2050/4885 |
| US-20100120719-A1 | LYOPHILIZATION FORMULATION | DPYD, TYMP, TYMS | HRH3 2659/4885HRH4 1679/4885PLD1 4209/4885 |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | HRH2, HRH4, HRH3 | HRH3 3/4885HRH4 2/4885PLD1 1534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.