Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 6/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | USP2 | O75604 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13018670 | 0.87 | HRH3 (0.76) | HRH3ALDH1A1HSD17B10CYP1A2HPGD | |
| SCHEMBL2167882 | 0.79 | HRH3 (1.00) | HRH3ALDH1A1HSD17B10CYP1A2HRH4 | |
| SCHEMBL27226470 | 0.78 | ALDH1A1 (0.54) | HRH3ALDH1A1HSD17B10CYP1A2HPGD | |
| Hydrochloric Acid SCHEMBL3781500 | 0.78 | HRH3 (0.97) | HRH3ALDH1A1HSD17B10CYP1A2HRH4 | |
| Hydrochloric Acid SCHEMBL26600058 | 0.78 | HRH3 (0.97) | HRH3ALDH1A1HSD17B10CYP1A2HRH4 | |
| SCHEMBL2166795 | 0.76 | HRH3 (1.00) | HRH3ALDH1A1HSD17B10HPGDHRH4 | |
| SCHEMBL13018739 | 0.75 | HRH3 (0.60) | HRH3ALDH1A1HSD17B10HPGDHRH4 | |
| SCHEMBL29946786 | 0.75 | ALDH1A1 (0.65) | ALDH1A1HSD17B10CYP1A2HPGDTSHR | |
| Hydrochloric Acid SCHEMBL3786113 | 0.75 | HRH3 (0.97) | HRH3ALDH1A1HSD17B10HPGDHRH4 | |
| SCHEMBL13018668 | 0.74 | HRH3 (0.88) | HRH3ALDH1A1HSD17B10CYP1A2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796297-B2 | 4-substituted-2-amino-pyrimidine derivatives | ABBVIE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796297-B2 | 4-substituted-2-amino-pyrimidine derivatives | ABBVIE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | HRH2, HRH4, HRH3 | HRH3 3/4885ALDH1A1 1078/4885HSD17B10 3863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.