Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20076168 | 0.79 | HAVCR2 (0.36) | HAVCR2HSD17B10XDHKDM4E | |
| SCHEMBL20075836 | 0.76 | ALDH1A1 (0.47) | HAVCR2HSD17B10XDHKDM4EALDH1A1 | |
| SCHEMBL20075842 | 0.72 | NPC1 (0.50) | XDHKDM4EALDH1A1HPGD | |
| SCHEMBL20076030 | 0.71 | PDE3B (0.35) | HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL20076037 | 0.71 | USP2 (0.34) | HAVCR2HSD17B10XDH | |
| SCHEMBL20588572 | 0.70 | HRH4 (0.35) | HSD17B10ALDH1A1HPGD | |
| SCHEMBL20074200 | 0.70 | TSHR (0.38) | XDHALDH1A1HPGD | |
| SCHEMBL20075884 | 0.67 | KDM5B (0.35) | HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL20588719 | 0.66 | KDM4E (0.44) | HAVCR2HSD17B10XDHKDM4EALDH1A1 | |
| SCHEMBL20076180 | 0.65 | KDM5B (0.35) | HSD17B10KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | claimed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
| US-20200048259-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048259-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | HAVCR2 4388/4885HSD17B10 1574/4885XDH 1849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.