Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 19/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2168778 | 1.00 | LTA4H (0.55) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2181683 | 1.00 | LTA4H (0.55) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2168304 | 1.00 | LTA4H (0.55) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2168228 | 0.86 | LTA4H (0.58) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2171516 | 0.86 | LTA4H (0.58) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL2178625 | 0.86 | LTA4H (0.58) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL5598251 | 0.86 | LTA4H (0.58) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL5598248 | 0.86 | LTA4H (0.58) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| Bicarbonate SCHEMBL4693510 | 0.85 | LTA4H (0.58) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 | |
| SCHEMBL23111535 | 0.83 | LTA4H (0.65) | LTA4HKCNH2EPHX2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4726238-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| WO-2008100564-A1 | LTA4H MODULATORS AND USES THEROF | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | claimed |
| EP-1660492-A1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2006-05-31 | — | — | EP | claimed |
| WO-2005012297-A1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-10 | — | — | WO | claimed |
| WO-2008100564-A1 | LTA4H MODULATORS AND USES THEROF | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | disclosed |
| WO-2005012297-A9 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2007-01-04 | — | — | WO | disclosed |