Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL10615466 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28425174 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL15667261 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28361772 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL10908368 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7946477 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL6387459 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL14335790 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL10952174 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28731062 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4552 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4261265-B1 | PLUGGING AGENT FOR OIL EXTRACTION IN OILFIELD AND A PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | CHINA PETROLEUM & CHEM CORP (CN) | 2026-05-27 | — | — | EP | claimed |
| CN-122094704-A | Formulations for oral administration of active agents comprising a combination of acid-neutralizing polymer and non-polymeric material | — | 2026-05-26 | — | — | CN | claimed |
| CN-122080316-A | Water-dispersible cationic polyacrylamide material and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-121736172-B | Composition for controlled release type ultrahigh temperature resistant salt resistant gel, preparation method and application thereof | 中国石油大学(北京) | 2026-05-19 | — | — | CN | claimed |
| CN-119432353-B | Crosslinking agent, preparation method thereof and viscosity-variable fracturing fluid | 中石化石油工程技术服务股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122011276-A | Oil reservoir deep profile control and flooding combined particle, and preparation method and application thereof | 中海石油（中国）有限公司天津分公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4734174-A1 | GRAPHITE COMPOSITE MATERIAL AND PREPARATION METHOD THEREFOR, NEGATIVE ELECTRODE ACTIVE MATERIAL, SECONDARY BATTERY, AND ELECTRIC DEVICE | SVOLT Energy Technology Co., Ltd. (CN) | 2026-04-29 | — | — | EP | claimed |
| US-12601064-B2 | Corrosion control for water systems using passivators and a hydroxycarboxylic acid | CHEMTREAT, INC. (US) | 2026-04-14 | — | — | US | claimed |
| CN-121584024-A | Electrolyte and lithium ion battery | 横店集团东磁股份有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-12492333-B2 | Method of treating a subterranean formation with delayed acid system | BAKER HUGHES OILFIELD OPERATIONS LLC (US) | 2025-12-09 | — | — | US | claimed |
| EP-0176991-A1 | Composition and method for corrosion inhibition | PHILLIPS PETROLEUM COMPANY (US) | 1986-04-09 | — | — | EP | claimed |
| US-4560783-A | Process for producing aluminum citrate solutions | PHILLIPS PETROLEUM COMPANY (US) | 1985-12-24 | — | — | US | claimed |
| US-4488601-A | Control of aluminum cross-linked polyacrylamides for sweep improvement | THE STANDARD OIL COMPANY (US) | 1984-12-18 | — | — | US | claimed |
| US-4447364-A | AGITATION CITRIC ACID AND ALUMINUM CHLORIDE, THEN ADJUSTMENT OF PH | MILES LABORATORIES, INC. (US) | 1984-05-08 | — | — | US | claimed |
| EP-0040763-B1 | METHOD FOR THE PREPARATION OF LIQUID ALUMINUM CITRATE | MILES LABORATORIES, INC. (US) | 1983-09-07 | — | — | EP | claimed |
| EP-0040763-A1 | Method for the preparation of liquid aluminum citrate | MILES LABORATORIES, INC. (US) | 1981-12-02 | — | — | EP | claimed |
| US-4274427-A | SALT FILLERS RETAIN THE EXPANDED BULK | PHILIP MORRIS INCORPORATED (US) | 1981-06-23 | — | — | US | claimed |
| US-3981363-A | Partially crosslinked polymer used in correcting subterranean formation permeability | PHILLIPS PETROLEUM COMPANY (US) | 1976-09-21 | — | — | US | claimed |
| US-3964255-A | Method of inflating an automobile passenger restraint bag | SPECIALTY PRODUCTS DEVELOPMENT CORPORATION (US) | 1976-06-22 | — | — | US | claimed |
| US-3952806-A | Method for altering permeability of a hydrocarbon-containing formation | PHILLIPS PETROLEUM COMPANY (US) | 1976-04-27 | — | — | US | claimed |