SCHEMBL2168586

SCHEMBL2168586

O=C(c1ccc(Cl)cc1)c1ccc(-c2ccc(O)cc2)cc1

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.87
LMNA P02545 2/20 0.67
MAPT P10636 2/20 0.67
RAB9A P51151 2/20 0.67
MEN1 O00255 1/20 0.67
KMT2A Q03164 1/20 0.67
HPGD P15428 2/20 0.65
ESR1 P03372 1/20 0.65
ESR2 Q92731 1/20 0.65
PKM P14618 1/20 0.65
HTT P42858 1/20 0.65
SRD5A2 P31213 2/20 0.59
CNR1 P21554 1/20 0.55
CNR2 P34972 1/20 0.55
HSD17B1 P14061 1/20 0.54
PDPK1 O15530 1/20 0.53
MMP2 P08253 1/20 0.53
MMP3 P08254 1/20 0.53
NPC1 O15118 1/20 0.53
DEGS1 O15121 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9777922 1.00 MAPK1 (0.87) MAPK1LMNAMAPTRAB9AMEN1
SCHEMBL9248915 1.00 MAPK1 (0.87) MAPK1LMNAMAPTRAB9AMEN1
SCHEMBL9457019 0.93 MAPK1 (1.00) MAPK1LMNAMAPTRAB9AMEN1
Hydroquinone SCHEMBL9777901 0.93 MAPK1 (1.00) MAPK1LMNAMAPTRAB9AMEN1
Hydroquinone SCHEMBL10635396 0.93 MAPK1 (1.00) MAPK1LMNAMAPTRAB9AMEN1
SCHEMBL333466 0.93 MAPK1 (1.00) MAPK1LMNAMAPTRAB9AMEN1
SCHEMBL9777896 0.93 MAPK1 (1.00) MAPK1LMNAMAPTRAB9AMEN1
Hydroquinone SCHEMBL9777898 0.91 MAPK1 (0.95) MAPK1LMNAMAPTRAB9AMEN1
SCHEMBL29217821 0.91 MAPK1 (0.95) MAPK1LMNAMAPTRAB9AMEN1
SCHEMBL30496095 0.91 MAPK1 (0.95) MAPK1LMNAMAPTRAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0306051-B1 Process for production of aromatic polyethers MITSUBISHI GAS CHEMICAL CO (JP) 1996-03-06 EP claimed
EP-0306051-A1 Process for production of aromatic polyethers MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1989-03-08 EP claimed
EP-0232019-A2 Aromatic Polymer IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-08-12 EP claimed
JP-7033740-A None JP disclosed
JP-4359021-A None JP disclosed
US-10364352-B2 High temperature melt processable semi-crystalline poly(aryl ether ketone) containing a (4-hydroxyphenyl)phthalazin-1(2h)-one comonomer unit POLYMICS, LTD (US) 2019-07-30 US disclosed
US-10189991-B2 High temperature melt processable semi-crystalline poly (aryl ether ketone) containing a (4-hydroxyphenyl) phthalazin-1 (2H)-one comonomer unit POLYMICS, LTD (US) 2019-01-29 US disclosed
EP-2346921-B1 HIGH TEMPERATURE MELT PROCESSABLE SEMI-CRYSTALLINE POLY (ARYL ETHER KETONE) CONTAINING A (4-HYDROXYPHENYL) PHTHALAZIN-1(2H)-ONE COMONOMER UNIT POLYMICS LTD (US) 2019-01-02 EP disclosed
US-20110206880-A1 HIGH TEMPERATURE MELT PROCESSABLE SEMI-CRYSTALLINE POLY(ARYL ETHER KETONE) CONTAINING A (4-HYDROXYPHENYL)PHTHALAZIN-1(2H)-ONE COMONOMER UNIT WANG YI-FENG 2011-08-25 US disclosed
EP-2346921-A1 HIGH TEMPERATURE MELT PROCESSABLE SEMI-CRYSTALLINE POLY (ARYL ETHER KETONE) CONTAINING A (4-HYDROXYPHENYL) PHTHALAZIN-1(2H)-ONE COMONOMER UNIT Polymics, Ltd. (US) 2011-07-27 EP disclosed
WO-2010062361-A1 HIGH TEMPERATURE MELT PROCESSABLE SEMI-CRYSTALLINE POLY (ARYL ETHER KETONE) CONTAINING A (4-HYDROXYPHENYL) PHTHALAZIN-1(2H)-ONE COMONOMER UNIT POLYMICS, LTD (US) 2010-06-03 WO disclosed
US-4868273-A SOLVENT RESISTANT POLYETHERS CONTAINING SULFONE AND CARBONYL GROUPS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1989-09-19 US disclosed
EP-0303389-A2 Aromatic polymer IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1989-02-15 EP disclosed
US-4777300-A Aromatic ketone IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-10-11 US disclosed
US-4711945-A Polyketone IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-12-08 US disclosed
EP-0232019-A2 Aromatic Polymer IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-08-12 EP disclosed
EP-0222536-A2 Aromatic polymer and process for its preparation IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-05-20 EP disclosed
EP-0182648-A2 Process for the Preparation of Polyetherketones IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-05-28 EP disclosed
EP-0075390-A1 Production of arylophenones IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-03-30 EP disclosed
US-4113699-A POLYETHER KETONES FROM HALOPHENOLS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1978-09-12 US disclosed