⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16366005 | 1.00 | — | — | |
| SCHEMBL797865 | 1.00 | — | — | |
| SCHEMBL798189 | 1.00 | — | — | |
| SCHEMBL7073737 | 1.00 | — | — | |
| SCHEMBL15809714 | 1.00 | — | — | |
| SCHEMBL28742938 | 0.84 | — | — | |
| SCHEMBL24299777 | 0.81 | — | — | |
| SCHEMBL14543908 | 0.81 | — | — | |
| SCHEMBL13428769 | 0.81 | — | — | |
| SCHEMBL7654633 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1700854-B1 | Intermediates for the preparation of 2-(6-substituted-1,3-dioxane-4-yl) acetic acid derivatives | ASTRAZENECA UK LTD (GB) | 2012-05-23 | — | — | EP | claimed |
| US-20110251406-A1 | PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,-3-DIOXANE-4-YL) ACETIC ACID DERIVATIVES | ASTRAZENECA UK LTD. (GB) | 2011-10-13 | — | — | US | claimed |
| EP-2788342-B1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | DSM SINOCHEM PHARM NL BV (NL) | 2018-01-24 | — | — | EP | disclosed |
| EP-2655650-B1 | ENZYMATIC SYNTHESIS OF ACTIVE PHARMACEUTICAL INGREDIENT AND INTERMEDIATES THEREOF | LEK PHARMACEUTICALS (SI) | 2017-12-20 | — | — | EP | disclosed |
| EP-2788341-B1 | PROCESS FOR THE PREPARATION OF A THIOPRECURSOR FOR STATINS | DSM SINOCHEM PHARM NL BV (NL) | 2017-04-05 | — | — | EP | disclosed |
| EP-2665722-B1 | PROCESS FOR THE PREPARATION OF DIOL SULFONES | DSM SINOCHEM PHARM NL BV (NL) | 2016-08-17 | — | — | EP | disclosed |
| EP-2665722-B1 | PROCESS FOR THE PREPARATION OF DIOL SULFONES | DSM SINOCHEM PHARM NL BV (NL) | 2016-08-17 | — | — | EP | disclosed |
| US-9260423-B2 | Process for the preparation of a thioprecursor for statins | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2016-02-16 | — | — | US | disclosed |
| US-9150562-B2 | Process for the preparation of diol sulfones | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2015-10-06 | — | — | US | disclosed |
| US-9150562-B2 | Process for the preparation of diol sulfones | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2015-10-06 | — | — | US | disclosed |
| US-9150562-B2 | Process for the preparation of diol sulfones | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2015-10-06 | — | — | US | disclosed |
| WO-2007039287-A1 | PROCESS FOR THE SYNTHESIS OF HMG-CoA REDUCTASE INHIBITORS | LEK PHARMACEUTICALS D.D. (SI) | 2007-04-12 | — | — | WO | disclosed |
| US-20060258733-A1 | By reacting 2-(leaving group-methyl)-4-hydroxy-6-oxotetrahydropyran with a cyanide ion in water at a pH of 0-5; nitrile may be reduced to form an aminoethyl group; reacting with an acetal-forming agent to form a 1,3-dioxane derivative; may be further converted to atorvastatin or its calcium salt | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2006-11-16 | — | — | US | disclosed |
| EP-1317440-B1 | PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,3-DIOXANE-4-YL)ACETIC ACID DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2006-09-27 | — | — | EP | disclosed |
| EP-1700854-A1 | Process for the preparation of 2-(6-substituted-1,3-dioxane-4-yl) acetic acid derivatives | AstraZeneca UK Limited (GB) | 2006-09-13 | — | — | EP | disclosed |
| US-20050148785-A1 | Process for the preparation of 2-(6-substituted-1,-3-dioxane-4-YL) acetic acid derivatives | ASTRAZENECA UK LTD. | 2005-07-07 | — | — | US | disclosed |
| US-6870059-B2 | Process for the preparation of 2-(6-substituted-1,-3-dioxane-4-yl)acetic acid derivatives | ASTRAZENECA UK LTD. (GB) | 2005-03-22 | — | — | US | disclosed |
| US-20030158426-A1 | Process for the preparation of 2-(6-subtituted-1,-3-dioxane-4-yl)acetic acid derivatives | ASTRAZENECA UK LTD. (GB) | 2003-08-21 | — | — | US | disclosed |
| EP-1317440-A1 | PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,3-DIOXANE-4-YL)ACETIC ACID DERIVATIVES | DSM N.V. (NL) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002006266-A1 | PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,3-DIOXANE-4-YL)ACETIC ACID DERIVATIVES | DSM N.V. (NL) | 2002-01-24 | — | — | WO | disclosed |