SCHEMBL798189

SCHEMBL798189

O=C1CC(O)CC(CCl)O1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16366005 1.00
SCHEMBL797865 1.00
SCHEMBL7073737 1.00
SCHEMBL2168636 1.00
SCHEMBL15809714 1.00
SCHEMBL28742938 0.84
SCHEMBL24299777 0.81
SCHEMBL14543908 0.81
SCHEMBL13428769 0.81
SCHEMBL7654633 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013068917-A1 PROCESSES FOR THE PRODUCTION OF A LACTONE STATIN INTERMEDIATE BY ENZYMATIC OXIDATION DR. REDDY'S LABORATORIES LIMITED (IN) 2013-05-16 WO claimed
US-5292891-A Optically active 2,2-dimethyl-1,3-dioxin-4-ones and method for preparing same and method for preparing optically active compound for synthesis of physiologically active substance and optically active intermediate compound CHISSO CORPORATION (JP) 1994-03-08 US claimed
US-10544119-B2 Preparation method for chiral intermediate for use in statins ASYMCHEM LABORATORIES (TIANJIN) CO., LTD. (CN) 2020-01-28 US disclosed
US-10544119-B2 Preparation method for chiral intermediate for use in statins ASYMCHEM LABORATORIES (TIANJIN) CO., LTD. (CN) 2020-01-28 US disclosed
US-20180072696-A1 SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES NATIONAL SCIENCE FOUNDATION 2018-03-15 US disclosed
EP-3141544-B1 PREPARATION METHOD FOR CHIRAL INTERMEDIATE FOR USE IN STATINS ASYMCHEM LABORATORIES (TIANJIN) CO LTD (CN) 2018-02-07 EP disclosed
EP-3141544-B1 PREPARATION METHOD FOR CHIRAL INTERMEDIATE FOR USE IN STATINS ASYMCHEM LABORATORIES (TIANJIN) CO LTD (CN) 2018-02-07 EP disclosed
CN-105272954-B A kind of preparation method of the ketone of 6 substituent methyl, 4 hydroxy tetrahydro pyrans 2 and its derivative 上海弈柯莱生物医药科技有限公司 2017-10-13 CN disclosed
US-20170190684-A1 PREPARATION METHOD FOR CHIRAL INTERMEDIATE FOR USE IN STATINS ASYMCHEM LABORATORIES (TIANJIN) CO., LTD. (CN) 2017-07-06 US disclosed
US-20170190684-A1 PREPARATION METHOD FOR CHIRAL INTERMEDIATE FOR USE IN STATINS ASYMCHEM LABORATORIES (TIANJIN) CO., LTD. (CN) 2017-07-06 US disclosed
US-20170190684-A1 PREPARATION METHOD FOR CHIRAL INTERMEDIATE FOR USE IN STATINS ASYMCHEM LABORATORIES (TIANJIN) CO., LTD. (CN) 2017-07-06 US disclosed
WO-2012034958-A1 ESTERS OF HEXANOIC ACIDS AS INTERMEDIATES FOR THE PREPARATION OF ATORVASTATIN DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) 2012-03-22 WO disclosed
US-20100145046-A1 Substituted 3-hydroxy-delta-lactones from epoxides ENERGY, UNITED STATES DEPARTMENT OF 2010-06-10 US disclosed
US-20100145046-A1 Substituted 3-hydroxy-delta-lactones from epoxides ENERGY, UNITED STATES DEPARTMENT OF 2010-06-10 US disclosed
WO-2007137816-A1 PROCESS FOR THE PREPARATION OF EPOXIDE INTERMEDIATES FOR PHARMACEUTICAL COMPOUNDS SUCH AS STATINS DSM IP ASSETS B.V. (NL) 2007-12-06 WO disclosed
EP-1317440-B1 PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,3-DIOXANE-4-YL)ACETIC ACID DERIVATIVES ASTRAZENECA UK LTD (GB) 2006-09-27 EP disclosed
EP-1317440-A1 PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,3-DIOXANE-4-YL)ACETIC ACID DERIVATIVES DSM N.V. (NL) 2003-06-11 EP disclosed
WO-2002006266-A1 PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,3-DIOXANE-4-YL)ACETIC ACID DERIVATIVES DSM N.V. (NL) 2002-01-24 WO disclosed
US-5292891-A Optically active 2,2-dimethyl-1,3-dioxin-4-ones and method for preparing same and method for preparing optically active compound for synthesis of physiologically active substance and optically active intermediate compound CHISSO CORPORATION (JP) 1994-03-08 US disclosed
US-5292891-A Optically active 2,2-dimethyl-1,3-dioxin-4-ones and method for preparing same and method for preparing optically active compound for synthesis of physiologically active substance and optically active intermediate compound CHISSO CORPORATION (JP) 1994-03-08 US disclosed