Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 3/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30763407 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL21686826 | 0.82 | HRH4 (0.75) | HRH1HRH4PDE5A | |
| SCHEMBL30763423 | 0.82 | HRH4 (0.75) | HRH1HRH4PDE5A | |
| SCHEMBL21686870 | 0.81 | HRH4 (0.60) | NPC1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL21686911 | 0.81 | HRH4 (0.62) | NPC1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL30763389 | 0.81 | HRH4 (0.60) | NPC1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3643331 | 0.81 | MEN1 (0.70) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL23855480 | 0.80 | HRH4 (0.59) | NPC1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL21686978 | 0.80 | CHRM3 (0.49) | SMN1; SMN2NPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL21687030 | 0.80 | HRH4 (0.59) | NPC1HRH1HRH4PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12492199-B2 | Pyridopyrimidines as histamine H4-receptor inhibitors | FAES FARMA, S.A. (ES) | 2025-12-09 | — | — | US | disclosed |
| EP-3827005-B1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | FAES FARMA SA (ES) | 2022-08-17 | — | — | EP | disclosed |
| US-20210300922-A1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | FAES FARMA, S.A. (ES) | 2021-09-30 | — | — | US | disclosed |
| US-20210300922-A1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | FAES FARMA, S.A. (ES) | 2021-09-30 | — | — | US | disclosed |
| WO-2020020939-A1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | FAES FARMA, S.A. (ES) | 2020-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300922-A1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | HRH4, HRH3, HRH2 | SMN1; SMN2 2547/4885NPC1 2970/4885MEN1 1581/4885 |
| US-12492199-B2 | Pyridopyrimidines as histamine H4-receptor inhibitors | HRH4, HRH2, HRH3 | SMN1; SMN2 3717/4885NPC1 1950/4885MEN1 1177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.