Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | RORC | P51449 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929705 | 0.94 | CNR1 (0.56) | CNR1RORCALDH1A1HTTLMNA | |
| SCHEMBL21696206 | 0.94 | RORC (0.54) | CNR1RORCALDH1A1HTTLMNA | |
| SCHEMBL15001567 | 0.93 | RORC (0.60) | CNR1RORCALDH1A1HTTLMNA | |
| SCHEMBL3921347 | 0.93 | CNR1 (0.54) | CNR1RORCALDH1A1HTTLMNA | |
| SCHEMBL16261327 | 0.91 | RORC (0.55) | CNR1RORCALDH1A1HTTLMNA | |
| SCHEMBL16259834 | 0.89 | CNR1 (0.48) | CNR1RORCALDH1A1HTTLMNA | |
| SCHEMBL14999538 | 0.86 | RORC (0.51) | CNR1RORCALDH1A1HTTLMNA | |
| SCHEMBL15001615 | 0.86 | RORC (0.54) | CNR1RORCALDH1A1HTTLMNA | |
| SCHEMBL15001609 | 0.85 | CNR1 (0.45) | CNR1RORCHTR2AHTR2CSLC6A4 | |
| SCHEMBL21696220 | 0.85 | CNR1 (0.50) | CNR1RORCALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2800745-B1 | PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORY, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES | PHENEX PHARMACEUTICALS AG (DE) | 2020-02-12 | — | — | EP | disclosed |